故事讲述两个在当代具有超自然能力的人“乔治”和“米歇尔”。在当地一个不知名的医院里做苦工，他们生活绝望-因为米歇尔是吸血鬼，乔治是狼人。他们决定改过自新，住在了一起才发现，一个女鬼(Annie)死于神秘的情况并且经常闹鬼。在这个一个对两个人的竞赛中(Threesome 有三人一组或者一人对抗两人的意思，这里应该指安妮女鬼和乔治米歇尔搭档)，他们与超自然生物对抗，希望通过这样的生活方式与他们的邻居-人类相处。
　　Contemporary Supernatural Drama About George And Mitchell, A Pair Of Perennial Outsiders. Working In The Anonymous Drudgery Of The Local Hospital, They Live Lives Of Quiet Desperation - Because Mitchell Is A Vampire And George Is A Werewolf. Deciding To Turn Over A New Leaf, They Move Into A House Together, Only To Find That It Is Haunted By Annie, The Ghost Of A Woman Killed In Mysterious Circumstances. As A Threesome, They Deal With The Challenges Of Being Supernatural Creatures, Bonded By Their Desire To Adopt The Lifestyle Of Their Neighbours - Humanity.

　　Three months after the Frobisher settlement, Patty is concentrating on establishing a charitable foundation when an old boyfriend, named Daniel Purcell, contacts her and entangles her in a new case involving corporate fraud and greed. Meanwhile, Ellen continues working with the FBI to destroy Patty, but she becomes more rash and impatient as she continues to set up her appearances to hide her rage behind fabricated grief in the wake of David's murder. Elsewhere, Arthur Frobisher is revealed to have survived the assassination attempt and is recovering in seclusion as he plots his next move against all the people whom he felt wronged him.