本剧叙述在野党影子内阁成员Jim Hacker在帮助本党大选获胜之后得到行政事务部（DAA）部长的职务，从此开始面对以部秘书Sir Humphrey Appleby为首的公务员体系，而他的公派私人秘书、同属公务员的Bernard则夹在了当中。在Hacker所代表的政客以及Appleby所代表的公务员之间因施政而发生的种种冲突之中，两人的关系不停地发生变化，既有互相捂盖子，也有互相揭老底。与此同时，英国政治体制（包括政党体制和公务员体制）中的种种不为外人所知弊端和黑幕也展现在观众眼前。当然所有这些都是通过大量喜剧情节和台词展开。在本系列后半部分的《Yes Prime Minister》中，Hacker通过党内角力当上了首相，而Appleby也已先他一步当上了首相秘书，两人的故事移到唐宁街10号继续展开。
一位年轻女医生的私生活陷入困境后，为寻求新的开始，接手柏林最艰难、最混乱医院的急诊室。面对员工的抵触和破旧系统的同时，她必须团结这支特立独行的团队来挽救生命。
Answering Fire - In a suspected terrorist attack on a London hotel a government minister is killed. As Sam and the team investigate the case, old friends and government officials soon muddy the water. Fatal Error - When two brothers are found dead in a police cell, Sam and Leo find themselves on opposing sides of an Old Bailey court case – then a 13-year old murder resurfaces, questioning Sam’s findings… Running on Empty - When a young woman falls to her death, the police believe she took her own life. When Sam, Leo and Harry are called in, their investigations soon unravel a tragic story. Beyond Guilt - As Sam investigates a brutal murder, she is also asked to investigate a professor linked to the case and discovers the case is a lot more complicated than first appearances suggested.
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